SIDE EFFECTS OF TAMOXIFEN:
Hot flushes, oedema, fluid retention, dry skin, vaginal bleeding, vaginal discharge, pruritus vulvae, GI upsets, nausea, dizziness, rashes, blurred vision, loss of acuity, alopecia, increased liver enzymes, hypertriglyceridaemia, uterine fibroids and endometrial hyperplasia. Potentially Fatal: Blood dyscrasias, cholestasis, hepatitis, hypercalcaemia in patients with bone metastasis, thromboembolic events. Increased risk of endometrial cancer and uterine sarcoma.
DRUG INTERACTIONS OF TAMOXIFEN:
Aminoglutethimide reduces plasma-tamoxifen concentration. Potentially Fatal: Concurrent use increased anticoagulant effect of warfarin; increased risk of thromboembolic events with other cytotoxic drugs.
CONTRAINDICATIONS OF TAMOXIFEN:
Pregnancy and lactation. History of thromboembolic events.
SPECIAL PRECAUTIONS FOR TAMOXIFEN:
Perform routine haematological and liver function tests in long-term therapy. Gynaecological monitoring is necessary in women.